Use of aminoglycosides in animals in the European Union: development of resistance and impact on human and animal health - Scientific guideline

The purpose of the reflection paper, which was developed by EMA's Antimicrobials Working Party, and adopted by the Committee for Medicinal Products for Veterinary Use (CVMP), is to critically review the current knowledge on the usage of aminoglycosides, the development of resistance and the potential impact of this resistance on animal and human health. On this basis, the paper makes recommendations on how these medicines should be used in animals to maintain their effectiveness to treat infections in both humans and animals.

Keywords: Amynoglycosides, development in resistance, veterinary antimicrobial agents, antimicrobial resistance

Current effective version

Reflection paper on use of aminoglycosides in animals in the European Union: development of resistance and impact on human and animal health

AdoptedReference Number: EMA/CVMP/AWP/721118/2014

Document history

Overview of comments received on 'Reflection paper on use of aminoglycosides in animals in the European Union: development of resistance and impact on human and animal health' (EMA/CVMP/AWP/721118/2014)

Reference Number: EMA/CVMP/AWP/726389/2017

Draft reflection paper on use of aminoglycosides in animals in the European Union: development of resistance and impact on human and animal health

Consultation dates: 25/07/2017 to 31/10/2017Draft: consultation closedReference Number: EMA/CVMP/AWP/721118/2014

Concept paper on use of aminoglycosides in animals in the European Union: Development of resistance and impact on human and animal health

Consultation dates: 23/07/2014 to 31/10/2014Draft: consultation closedReference Number: EMA/CVMP/AWP/158821/2014Summary:

Aminoglycosides have a broad antibacterial spectrum with good activity against Gram-negative species and less activity against Gram-positive species. Emerging aminoglycoside resistance in bacteria of animal and human origin has raised concern as to whether aminoglycoside use in veterinary medicine could have a negative impact on public and animal health. Loss of efficacy of aminoglycosides could have a serious negative impact on animal health and welfare. The reflection paper should address the impact of use of aminoglycosides in animals on public and animal health.